Our research focuses on applying high-resolution nuclear magnetic resonance (NMR), together with other biophysical techniques, to study macromolecular structure, interactions and function.   Current projects in the laboratory aim to understand the role of RNA/DNA structures and interactions in plasmid copy number regulation and retroviral replication and the structural basis for guanine nucleotide exchange in G Protein Coupled Receptor signaling.  To advance our studies, we are involved in developing new NMR and fluorescence methods for characterizing macromolecular structure, dynamics and interactions.